Hi Katie,
I'll tell you my experience. I set up some profiles for items I was selling for our church. After they were sold I deleted the profiles I had identified for them.
After reading your post I checked some of those items in my saved folder. I'm happy to report they still had the profiles I had used for them.
I can't guarantee that will be your experience, but it is mine.
If you have not done so, I would highly recommend that you go through the tutorials for Profiles. They will really help you get all your profiles set up and this really saves time.
Happy selling