Hi deangelo,
I'm sorry to hear about the difficulties you are experiencing. I am not aware of any current technical issues that would prevent you from being able to create a shipping profile for use with the eBay UK site, so we will need to look into this further to determine why you have not been able to do so successfully.
Please contact our Customer Support team directly from under the “Help” tab within your account and we will be happy to continue working with you on this. It would be helpful if you can let us know exactly what you are trying to save in the profile in case the problem is related to a certain entry.
-Mike